Buy Safe and Effective Supplements

Don’t buy any more supplements until you read this article.

Why? A supplement you buy without doing your homework may be contaminated or mislabeled.

    • The Federal Drug Administration found problems and sent warning notices to 62% of the supplement manufacturing sites in U.S. and abroad that it inspected in its fiscal year ending September 30,

Maintain Your Brain – Introduction

Learn How to MaintainYour Brain

How to maintain a healthy brain and a good memory? How to be mentally capable and strong, thinking clearly and effectively throughout your life? How to avoid – and help people you care about – avoid cognitive (mental) decline and Alzheimer’s disease?

Where can we find the best and most complete source of information on avoiding cognitive decline (a decrease in one’s ability to think,

Maintain Your Brain – Part 3: Addressing the Threats

Why Anti-Alzheimer’s Drugs Don’t Work All By Themselves

Dr. Bredesen and his research team have identified thirty-six individual factors that contribute to the risk for Alzheimer’s. If enough (or a critical combination) of these factors exist, Alzheimer’s sets in. A prescription drug such as memantine may address one factor but leave other factors unaddressed so the progression into Alzheimer’s is not halted.

Maintain Your Brain – Conclusion: The Key Concepts and Recommendations

ReCODE: Key Concepts for a Healthy Brain

This is the final article in a series of six articles based upon the research and conclusions of Dale Bredesen, M.D. as published in his book, The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.1 The first article in the series can be found here: Maintain Your Brain –

Maintain Your Brain – Appendix B

Life history can provide crucial clues to what is causing Alzheimer’s disease, MCI or SCI. It is therefore important to know if you currently or have ever:

  1. suffered head trauma. (Have you ever been knocked unconscious?
  2. Had an automobile accident? Played contact sports?)
  3. had general anesthesia (and how many times).

Maintain Your Brain – Appendix A

No single drug is optimal to keep the brain on the healthy pathway . . . Why?

Such a drug would have to do all of the following:

    1. Reduce APPβ-cleavage
    2. Reduce γ-cleavage
    3. Increase α-cleavage
    4. Reduce caspase-6 cleavage
    5. Reduce caspase-3 cleavage
    6. Prevent amyloid-beta oligomerization
    7. Increase neprilysin
    8. Increase IDE (insulin-degrading enzyme)
    9. Increase microglial clearance of Aβ
    10. Increase autophagy
    11. Increase BDNF (brain-derived neurotrophic factor)
    12. Increase NGF (nerve growth factor)
    13. Increase netrin-1
    14. Increase ADNP (activity-dependent neuroprotective protein)
    15. Increase VIP (vasoactive intestinal peptide)
    16. Reduce homocysteine
    17. Increase PP2A (protein phosphatase 2A) activity
    18. Reduce phospho-tau Increase phagocytosis index
    19. Increase insulin sensitivity
    20. Enhance leptin sensitivity
    21. Improve axoplasmic transport
    22. Enhance mitochondrial function and biogenesis
    23. Reduce oxidative damage and optimize ROS (reactive oxygen species) production Enhance cholinergic neurotransmission
    24. Increase synaptoblastic signaling
    25. Reduce synaptoclastic signaling
    26. Improve LTP (long-term potentiation)
    27. Optimize estradiol
    28. Optimize progesterone
    29. Optimize E2: P (estradiol to progesterone) ratio
    30. Optimize free T3
    31. Optimize free T4
    32. Optimize TSH (thyroid-stimulating hormone)
    33. Optimize pregnenolone
    34. Optimize testosterone
    35. Optimize cortisol
    36. Optimize DHEA (dehydroepiandrosterone)
    37. Optimize insulin secretion and signaling
    38. Activate PPAR-γ (peroxisome proliferator-activated receptor gamma)
    39. Reduce inflammation
    40. Increase resolvins
    41. Enhance detoxification
    42. Improve vascularization
    43. Increase cAMP (cyclic adenosine monophosphate)
    44. Increase glutathione
    45. Provide synaptic components
    46. Optimize all metals I
    47. ncrease GABA (gamma-aminobutyric acid)
    48. Increase vitamin D signaling Increase SirT1 (silent information regulator T1)
    49. Reduce NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)
    50. Increase telomere length
    51. Reduce glial scarring
    52. Enhance stem-cell-mediated brain repair

And even this list may not be exhaustive.

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