Summary of the key tests and optional tests for the ReCODE protocol
Critical tests | Target values | Optional tests | |
Genetics | ApoE | Negative for ApoE4 | Whole genome, |
exome or SNPs | |||
Blood tests | Critical tests | Target values | Optional tests |
Inflammation vs. cellular protection | hs-CRP | <0.9 | IL-6, TNFα |
Homocysteine | <7 | ||
Vitamins B6,, B12, and folate | B6 60 -100 B12 500-1500 folate 10-25 | ||
Vitamins C, D and E | C 1.3-2.5 D 50-80 E 12-20 | ||
Omega-6 to Omega 3 ratio | 0.5 to 3.0 | ||
A/G (albumin:globulin) ratio | >1.8 albumin >4.5 | ||
Fasting insulin, glucose, hemoglobin A1c | Fasting insulin >4.5 Fasting glucose >5.6 A1c <5.6 | Neural exam studies (p-tau, Aβ42, REST, cathepsin D, and IRS-1 phos. ratio | |
Body Mass Index (BMI) | 18-25 | ||
LDL-p or sdLDL or oxidized LDL | LDL-p 7000-1000 sdLDL <20 oxidized LDL <60 | ||
Cholesterol, HDL, triglycerides | Cholesterol >150 HDL >50 triglycerides <150 | ||
Glutathione | 5.0-5.5 | ||
RBC thiamine pyrophosphate | 100-150 | ||
Leaky gut, leaky blood-brain barrier, gluten sensitivity, autotibodies | Negative |
Blood tests | Critical tests | Target values | Optional tests |
Trophic support | Vitamin D | 50-80 | |
Estradiol (E2) progesterone (P) | Estradiol (E2) 50-250 progesterone (P) 1-20 | ||
Prenenolone, cortisoll, DHEA-sulfate | Prenenolone 50-100 cortisoll 10-18 DHEA-sulfate: women 350-430 men 400-500 | ||
Testosterone free testosterone | Testosterone 500-1000 free testosterone 6.5-15 | ||
Free T3 Free T4 Reverse T3 | Free T3 3.2-4.2 Free T4 1.3-1.8 Reverse T3 <20 | ||
TSH Ratio of Free T3 to Reverse T3 | TSH <2.0 Ratio of Free T3 to Reverse T3 >20 |
Blood tests | Critical tests | Target values | Optional tests |
Toxin-related | Mercury Lead Arsenic Cadmium | Mercury <5 Lead <2 Arsenic <7 Cadmium <2.5 | Quicksilver test: <50th percentile |
Copper:zinc ratio | 0.8-1.2 | RBC zinc; ceruloplasmin | |
C4a TGF-β1 MSH | C4a <2830 TGF-β1 <2380 MSH 35-81 | MMP9, VEGF, leptin, VIP, ADH, osmolality | |
HLA-DR/DQ | Benign |
Blood tests | Critical tests | Target values | Optional tests |
Metals (excluding those listed above as toxin-related) | RBC-Magnesium | 5.2-6.5 | |
Copper, zinc | 90-110 (both) | ||
Selenium | 110-150 | ||
Potassium | 4.5-5.5 | ||
Calcium | 8.5-10.5 |
Critical tests | Target values | Optional tests | |
Cognitive performance | CNS Vital Signs, BrainHQ or equivalent | >50th percentile for age, improving with practice | Novel object recognition |
Hippocampal, cortical volume | |||
Imaging | MRI with volumetrics | percentiles steady (or increasing) for age, >25th percentile | Retinal imaging |
Sleep | Sleep study | AHI <5/hr. | |
Microbiomes | Gut, oral, nasal | No pathogens |