Maintain Your Brain – Appendix C

Summary of the key tests and optional tests for the ReCODE protocol

Critical tests

Target values

Optional tests

Genetics

ApoE

Negative for ApoE4

Whole genome,

   exome or SNPs

Blood tests

Critical tests

Target values

Optional tests

Inflammation vs. cellular protection

hs-CRP

<0.9

IL-6, TNFα

Homocysteine

<7

Vitamins B6,, B12, and folate

B6 60 -100

B12  500-1500

folate  10-25

Vitamins C, D and E

C  1.3-2.5

D  50-80

E  12-20

Omega-6 to Omega 3                

                            ratio

0.5 to 3.0

A/G (albumin:globulin)

                            ratio

>1.8

albumin >4.5

Fasting insulin, glucose, hemoglobin A1c

Fasting insulin >4.5

Fasting glucose >5.6

A1c <5.6

Neural exam studies (p-tau, Aβ42, REST, cathepsin D, and IRS-1 phos. ratio

Body Mass Index (BMI)

18-25

LDL-p or

sdLDL or

oxidized LDL

LDL-p 7000-1000

sdLDL <20

oxidized LDL <60

Cholesterol,

HDL,

triglycerides

Cholesterol >150

HDL >50

triglycerides <150

Glutathione

5.0-5.5

RBC thiamine pyrophosphate

100-150

Leaky gut, leaky blood-brain barrier, gluten sensitivity, autotibodies

Negative

Blood tests

Critical tests

Target values

Optional tests

Trophic support

Vitamin D

50-80

Estradiol (E2)

progesterone (P)

Estradiol (E2) 50-250

progesterone (P) 1-20

Prenenolone,

cortisoll,

DHEA-sulfate

Prenenolone 50-100

cortisoll 10-18

DHEA-sulfate:

        women 350-430

             men 400-500

Testosterone

free testosterone

Testosterone  500-1000

free testosterone 6.5-15

Free T3

Free T4

Reverse T3

Free T3  3.2-4.2

Free T4  1.3-1.8

Reverse T3  <20

TSH

Ratio of Free T3 to Reverse T3 

TSH  <2.0

Ratio of Free T3 to Reverse T3  >20

Blood tests

Critical tests

Target values

Optional tests

Toxin-related

Mercury

Lead

Arsenic

Cadmium

Mercury   <5

Lead        <2

Arsenic    <7

Cadmium <2.5

Quicksilver test:

      <50th percentile

Copper:zinc ratio

0.8-1.2

RBC zinc;

ceruloplasmin

C4a

TGF-β1

MSH

C4a       <2830

TGF-β1 <2380

MSH       35-81   

MMP9, VEGF, leptin, VIP, ADH, osmolality

HLA-DR/DQ

Benign

Blood tests

Critical tests

Target values

Optional tests

Metals (excluding those listed above as toxin-related)

RBC-Magnesium

5.2-6.5

Copper, zinc

90-110 (both)

Selenium

110-150

Potassium

4.5-5.5

Calcium

8.5-10.5

Critical tests

Target values

Optional tests

Cognitive performance

CNS Vital Signs, BrainHQ or equivalent

>50th percentile for age, improving with practice

Novel object recognition

Hippocampal, cortical volume

Imaging

MRI with volumetrics

percentiles steady (or increasing) for age, >25th percentile

Retinal imaging

Sleep

Sleep study

AHI <5/hr.

Microbiomes

Gut, oral, nasal

No pathogens

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